![]() ![]() As a novel 3D technology to print a variety of biological materials containing viable cells, bioprinting has received increasing attention worldwide and widely applied for broad-spectrum applications of regenerative medicines, tissue engineering and transplantation, pharmaceutical field, and cancer therapy ( Ozbolat, 2015). Further, this review describes the opportunities and challenges of this 3D bioprinting technique to construct complex bio-inks with adjustable mechanical and biological integrity, and meanwhile, the current possible solutions are also conducted for providing some suggestive ideas on developing more advanced bioprinting products from the bench to the clinic.īioprinting is defined as the spatial patterning of living cells and other biologics using computer-aided interlayer deposition to stack and assemble them to fabricate the living tissues and organs. Herein, this review is mainly focused on the introduction of various natural polymers and synthetic polymers in hydrogel-based bioprinted scaffolds, which are systematically discussed via emphasizing on the fabrication condition, mechanical property, biocompatibility, biodegradability, and biological performance for cartilage tissue repair. Although more and more researchers have reported a number of literatures in this field, many challenges that should be addressed for the development of three-dimensional (3D) bioprinting constructs still exist. ![]() On account of the precise structural fabrication and mimicking complexity, hydrogel-based bio-inks are widely adopted for cartilage tissue engineering.
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January 2023
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